A dendritic cell-stromal axis maintains immune responses in lymph nodes
Identifieur interne : 002223 ( Main/Exploration ); précédent : 002222; suivant : 002224A dendritic cell-stromal axis maintains immune responses in lymph nodes
Auteurs : Varsha Kumar [États-Unis] ; Dragos C. Dasoveanu [États-Unis] ; Susan Chyou [États-Unis] ; Te-Chen Tzeng [États-Unis] ; Cristina Rozo [États-Unis] ; Yong Liang [États-Unis] ; William Stohl [États-Unis] ; Yang-Xin Fu [États-Unis] ; Nancy Ruddle [États-Unis] ; Theresa T. Lu [États-Unis]Source :
- Immunity [ 1074-7613 ] ; 2015.
Abstract
Within secondary lymphoid tissues, stromal reticular cells support lymphocyte function, and targeting reticular cells is a potential strategy for controlling pathogenic lymphocytes in disease. However, the mechanisms that regulate reticular cell function are not well understood. Here we found that during an immune response in lymph nodes, dendritic cells (DCs) maintain reticular cell survival in multiple compartments. DC-derived lymphotoxin beta receptor (LTβR) ligands were critical mediators, and LTβR signaling on reticular cells mediated cell survival by modulating podoplanin (PDPN). PDPN modulated integrin-mediated cell adhesion, which maintained cell survival. This DC-stromal axis maintained lymphocyte survival and the ongoing immune response. Our findings provide insight into the functions of DCs, LTβR, and PDPN and delineate a DC-stromal axis that can potentially be targeted in autoimmune or lymphoproliferative diseases.
Url:
DOI: 10.1016/j.immuni.2015.03.015
PubMed: 25902483
PubMed Central: 4591553
Affiliations:
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Lu</name><affiliation wicri:level="1"><nlm:aff id="A1">Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25902483</idno><idno type="pmc">4591553</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591553</idno><idno type="RBID">PMC:4591553</idno><idno type="doi">10.1016/j.immuni.2015.03.015</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">003A01</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003A01</idno><idno type="wicri:Area/Pmc/Curation">003A00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003A00</idno><idno type="wicri:Area/Pmc/Checkpoint">001568</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001568</idno><idno type="wicri:Area/Ncbi/Merge">007298</idno><idno type="wicri:Area/Ncbi/Curation">007298</idno><idno type="wicri:Area/Ncbi/Checkpoint">007298</idno><idno type="wicri:doubleKey">1074-7613:2015:Kumar V:a:dendritic:cell</idno><idno type="wicri:Area/Main/Merge">002226</idno><idno type="wicri:Area/Main/Curation">002223</idno><idno type="wicri:Area/Main/Exploration">002223</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A dendritic cell-stromal axis maintains immune responses in lymph nodes</title><author><name sortKey="Kumar, Varsha" sort="Kumar, Varsha" uniqKey="Kumar V" first="Varsha" last="Kumar">Varsha Kumar</name><affiliation wicri:level="1"><nlm:aff id="A1">Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation></author><author><name sortKey="Dasoveanu, Dragos C" sort="Dasoveanu, Dragos C" uniqKey="Dasoveanu D" first="Dragos C." last="Dasoveanu">Dragos C. Dasoveanu</name><affiliation wicri:level="1"><nlm:aff id="A1">Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation></author><author><name sortKey="Chyou, Susan" sort="Chyou, Susan" uniqKey="Chyou S" first="Susan" last="Chyou">Susan Chyou</name><affiliation wicri:level="1"><nlm:aff id="A1">Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation></author><author><name sortKey="Tzeng, Te Chen" sort="Tzeng, Te Chen" uniqKey="Tzeng T" first="Te-Chen" last="Tzeng">Te-Chen Tzeng</name><affiliation wicri:level="1"><nlm:aff id="A1">Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation></author><author><name sortKey="Rozo, Cristina" sort="Rozo, Cristina" uniqKey="Rozo C" first="Cristina" last="Rozo">Cristina Rozo</name><affiliation wicri:level="1"><nlm:aff id="A1">Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Yong" sort="Liang, Yong" uniqKey="Liang Y" first="Yong" last="Liang">Yong Liang</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, 60637</wicri:regionArea><wicri:noRegion>60637</wicri:noRegion></affiliation></author><author><name sortKey="Stohl, William" sort="Stohl, William" uniqKey="Stohl W" first="William" last="Stohl">William Stohl</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Rheumatology, Keck School of Medicine of USC, Los Angeles, CA, 90033, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Rheumatology, Keck School of Medicine of USC, Los Angeles, CA, 90033</wicri:regionArea><wicri:noRegion>90033</wicri:noRegion></affiliation></author><author><name sortKey="Fu, Yang Xin" sort="Fu, Yang Xin" uniqKey="Fu Y" first="Yang-Xin" last="Fu">Yang-Xin Fu</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, 60637</wicri:regionArea><wicri:noRegion>60637</wicri:noRegion></affiliation></author><author><name sortKey="Ruddle, Nancy" sort="Ruddle, Nancy" uniqKey="Ruddle N" first="Nancy" last="Ruddle">Nancy Ruddle</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06520</wicri:regionArea><wicri:noRegion>06520</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Theresa T" sort="Lu, Theresa T" uniqKey="Lu T" first="Theresa T." last="Lu">Theresa T. Lu</name><affiliation wicri:level="1"><nlm:aff id="A1">Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, 10021</wicri:regionArea><wicri:noRegion>10021</wicri:noRegion></affiliation></author></analytic><series><title level="j">Immunity</title><idno type="ISSN">1074-7613</idno><idno type="eISSN">1097-4180</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p id="P2">Within secondary lymphoid tissues, stromal reticular cells support lymphocyte function, and targeting reticular cells is a potential strategy for controlling pathogenic lymphocytes in disease. However, the mechanisms that regulate reticular cell function are not well understood. Here we found that during an immune response in lymph nodes, dendritic cells (DCs) maintain reticular cell survival in multiple compartments. DC-derived lymphotoxin beta receptor (LTβR) ligands were critical mediators, and LTβR signaling on reticular cells mediated cell survival by modulating podoplanin (PDPN). PDPN modulated integrin-mediated cell adhesion, which maintained cell survival. This DC-stromal axis maintained lymphocyte survival and the ongoing immune response. Our findings provide insight into the functions of DCs, LTβR, and PDPN and delineate a DC-stromal axis that can potentially be targeted in autoimmune or lymphoproliferative diseases.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kumar, Varsha" sort="Kumar, Varsha" uniqKey="Kumar V" first="Varsha" last="Kumar">Varsha Kumar</name></noRegion><name sortKey="Chyou, Susan" sort="Chyou, Susan" uniqKey="Chyou S" first="Susan" last="Chyou">Susan Chyou</name><name sortKey="Dasoveanu, Dragos C" sort="Dasoveanu, Dragos C" uniqKey="Dasoveanu D" first="Dragos C." last="Dasoveanu">Dragos C. Dasoveanu</name><name sortKey="Fu, Yang Xin" sort="Fu, Yang Xin" uniqKey="Fu Y" first="Yang-Xin" last="Fu">Yang-Xin Fu</name><name sortKey="Liang, Yong" sort="Liang, Yong" uniqKey="Liang Y" first="Yong" last="Liang">Yong Liang</name><name sortKey="Lu, Theresa T" sort="Lu, Theresa T" uniqKey="Lu T" first="Theresa T." last="Lu">Theresa T. Lu</name><name sortKey="Lu, Theresa T" sort="Lu, Theresa T" uniqKey="Lu T" first="Theresa T." last="Lu">Theresa T. Lu</name><name sortKey="Lu, Theresa T" sort="Lu, Theresa T" uniqKey="Lu T" first="Theresa T." last="Lu">Theresa T. Lu</name><name sortKey="Rozo, Cristina" sort="Rozo, Cristina" uniqKey="Rozo C" first="Cristina" last="Rozo">Cristina Rozo</name><name sortKey="Ruddle, Nancy" sort="Ruddle, Nancy" uniqKey="Ruddle N" first="Nancy" last="Ruddle">Nancy Ruddle</name><name sortKey="Stohl, William" sort="Stohl, William" uniqKey="Stohl W" first="William" last="Stohl">William Stohl</name><name sortKey="Tzeng, Te Chen" sort="Tzeng, Te Chen" uniqKey="Tzeng T" first="Te-Chen" last="Tzeng">Te-Chen Tzeng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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